Linda R Watkins Selected Research

Hyperalgesia

1/2022	Suppression of active phase voluntary wheel running in male rats by unilateral chronic constriction injury: Enduring therapeutic effects of a brief treatment of morphine combined with TLR4 or P2X7 antagonists.
1/2021	Toll-like receptor 2 and 4 antagonism for the treatment of experimental autoimmune encephalomyelitis (EAE)-related pain.
1/2020	Activation of sphingosine-1-phosphate receptor subtype 1 in the central nervous system contributes to morphine-induced hyperalgesia and antinociceptive tolerance in rodents.
1/2019	A single peri-sciatic nerve administration of the adenosine 2A receptor agonist ATL313 produces long-lasting anti-allodynia and anti-inflammatory effects in male rats.
1/2018	Protraction of neuropathic pain by morphine is mediated by spinal damage associated molecular patterns (DAMPs) in male rats.
1/2018	MicroRNA-124 and microRNA-146a both attenuate persistent neuropathic pain induced by morphine in male rats.
1/2018	Sustained reversal of central neuropathic pain induced by a single intrathecal injection of adenosine A2A receptor agonists.
1/2018	DREADDed microglia in pain: Implications for spinal inflammatory signaling in male rats.
8/2017	Constriction of the buccal branch of the facial nerve produces unilateral craniofacial allodynia.
1/2017	Supradural inflammatory soup in awake and freely moving rats induces facial allodynia that is blocked by putative immune modulators.

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Linda R Watkins Research Topics

Disease

74	Pain (Aches) 10/2021 - 01/2003
61	Hyperalgesia 01/2022 - 12/2001
52	Neuralgia (Stump Neuralgia) 10/2022 - 02/2003
15	Inflammation (Inflammations) 01/2021 - 01/2004
14	Neuroinflammatory Diseases 10/2021 - 10/2011
14	Chronic Pain 01/2021 - 03/2005
13	Infections 01/2022 - 02/2005
12	Shock 11/2014 - 01/2002
8	Opioid-Related Disorders (Opiate Addiction) 06/2015 - 02/2007
5	Bacterial Infections (Bacterial Infection) 07/2013 - 04/2008
5	Fever (Fevers) 10/2011 - 02/2003
4	Peripheral Nerve Injuries 01/2022 - 11/2008
4	Memory Disorders (Memory Loss) 01/2021 - 10/2004
4	Substance-Related Disorders (Drug Abuse) 01/2018 - 06/2011
4	Wounds and Injuries (Trauma) 01/2017 - 11/2012
4	Migraine Disorders (Migraine) 01/2017 - 09/2009
4	Respiratory Insufficiency (Respiratory Failure) 10/2014 - 11/2008
3	Multiple Sclerosis 01/2020 - 01/2017
3	Contusions 01/2019 - 01/2017
3	Escherichia coli Infections 01/2015 - 02/2010
3	AIDS-Related Complex (ARC) 08/2012 - 01/2010
2	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 01/2021 - 01/2017
2	Postoperative Cognitive Complications 01/2021 - 10/2012
2	Brain Diseases (Brain Disorder) 01/2021 - 05/2015
2	Ischemic Stroke 03/2018 - 01/2018
2	Spinal Cord Injuries (Spinal Cord Injury) 01/2018 - 11/2016
2	Obesity 10/2017 - 11/2014
2	Gliosis 03/2014 - 07/2012

Drug/Important Bio-Agent (IBA)

49	CytokinesIBA 01/2022 - 01/2003
26	Opioid Analgesics (Opioids)IBA 01/2021 - 11/2003
25	Morphine (MS Contin)FDA LinkGeneric 01/2022 - 01/2002
19	Toll-Like Receptor 4IBA 01/2021 - 07/2008
15	Proteins (Proteins, Gene)FDA Link 11/2019 - 04/2005
14	Interleukin-10 (Interleukin 10)IBA 11/2020 - 03/2004
13	Pharmaceutical PreparationsIBA 03/2018 - 12/2003
13	Interleukin-1 (Interleukin 1)IBA 08/2017 - 02/2003
9	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2019 - 02/2003
9	LipopolysaccharidesIBA 02/2015 - 12/2004
8	Interleukin-1 Receptors (Interleukin 1 Receptor)IBA 01/2021 - 03/2004
8	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2021 - 11/2007
8	Analgesics (Analgesic Drugs)IBA 09/2011 - 08/2004
7	Naltrexone (ReVia)FDA LinkGeneric 01/2021 - 07/2008
7	Minocycline (Cyclops)FDA LinkGeneric 01/2017 - 05/2005
7	ibudilastIBA 01/2017 - 11/2006
7	Interleukin-1beta (Interleukin 1 beta)IBA 11/2014 - 12/2003
7	Interleukin-6 (Interleukin 6)IBA 10/2011 - 02/2003
6	Messenger RNA (mRNA)IBA 01/2021 - 10/2004
6	HMGB1 Protein (HMG1)IBA 01/2018 - 12/2003
6	Brain-Derived Neurotrophic Factor (BDNF)IBA 08/2012 - 10/2004
5	ChemokinesIBA 01/2022 - 08/2004
5	Opioid Receptors (Opioid Receptor)IBA 01/2021 - 11/2009
5	Adenosine (Adenocard)FDA LinkGeneric 01/2019 - 11/2009
5	Naloxone (Narcan)FDA LinkGeneric 03/2018 - 07/2008
5	Serotonin (5 Hydroxytryptamine)IBA 01/2017 - 02/2002
5	Interleukin 1 Receptor Antagonist Protein (Anakinra)FDA Link 11/2012 - 08/2004
5	CorticosteroneIBA 10/2011 - 02/2003
4	ATL 313IBA 01/2019 - 11/2009
4	salicylhydroxamic acid (SHAM)IBA 01/2019 - 11/2009
4	GlucocorticoidsIBA 11/2018 - 06/2011
4	InflammasomesIBA 01/2018 - 08/2015
4	Dinoprostone (PGE2)FDA Link 01/2017 - 01/2010
3	MicroRNAs (MicroRNA)IBA 10/2021 - 01/2018
3	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)IBA 05/2021 - 08/2010
3	Neutralizing AntibodiesIBA 01/2019 - 03/2004
3	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2019 - 03/2004
3	NF-kappa B (NF-kB)IBA 01/2019 - 12/2004
3	Dopamine (Intropin)FDA LinkGeneric 01/2019 - 11/2007
3	Histamine (Histamine Dihydrochloride)FDA Link 01/2017 - 01/2010
3	BradykininIBA 01/2017 - 01/2010
3	Ethanol (Ethyl Alcohol)IBA 08/2015 - 05/2013
3	Freund's AdjuvantIBA 02/2014 - 01/2012
3	Formaldehyde (Formol)FDA Link 02/2014 - 10/2010
3	DNA (Deoxyribonucleic Acid)IBA 05/2010 - 12/2006
3	Glycoproteins (Glycoprotein)IBA 01/2010 - 10/2005
3	Chemokine CX3CL1IBA 09/2004 - 07/2004
2	Superoxides (Superoxide)IBA 10/2022 - 12/2016
2	Interleukin-17 (Interleukin 17)IBA 01/2021 - 01/2021
2	AntibodiesIBA 01/2021 - 11/2009
2	Toll-Like Receptor 2IBA 01/2021 - 05/2012
2	Fentanyl (Sublimaze)FDA LinkGeneric 11/2019 - 10/2014
2	NLR ProteinsIBA 01/2019 - 01/2016
2	2- (4- (2- carboxyethyl)phenethylamino)- 5'- N- ethylcarboxamidoadenosineIBA 01/2018 - 11/2009
2	Neurotransmitter Agents (Neurotransmitter)IBA 12/2016 - 03/2007
2	CeramidesIBA 04/2015 - 11/2010
2	morphine-3-glucuronideIBA 02/2015 - 05/2013
2	GlucuronidesIBA 02/2015 - 05/2013
2	ethyl glucuronideIBA 02/2015 - 05/2013
2	propentofyllineIBA 04/2014 - 04/2012
2	Neuroprotective AgentsIBA 03/2014 - 07/2012
2	TetracyclinesIBA 05/2013 - 03/2012

Therapy/Procedure

20	Therapeutics 01/2022 - 07/2004
12	Analgesia 01/2018 - 08/2004
10	Spinal Injections 01/2018 - 03/2005
4	Laparotomy 01/2019 - 10/2010
4	Injections 02/2012 - 12/2003
3	Ligation 10/2013 - 11/2006
3	Subcutaneous Injections 01/2012 - 03/2004
2	Drug Therapy (Chemotherapy) 01/2018 - 01/2003
2	Catheters 01/2017 - 01/2012
2	Pain Management 01/2016 - 04/2015